Bio Prototype Beginner’s Guide: Tips & Tricks for The Organic Action Roguelike

by Mike Alexander / Articles, Highlights / 03 Jan 2023

When Vampire Survivors launched last year, it kind of became a smash hit out of nowhere. Its concept is deceptively simple: your hero auto-fires whatever weapon or ability it possesses, and you move them around to avoid enemies long enough to clear waves and obtain upgrades that make you stronger.

The first time I played Vampire Survivors, I thought, “Man this is great, more games should do this”.

And here we are today, taking a look at Bio Prototype, an action roguelike of a similar nature being brought to us by Emprom Game and BD Games. Bio Prototype’s gameplay is just as simple as Vampire Survivors, but there’s much, much more going on under the hood. There’s so much nuance to each run that it can be a little overwhelming, which is exactly why I’m here today.

So get ready to do some genetic alterations, and let’s dig into the tips & tricks!

Save Cells in Early Waves

After each wave of enemies, you will be presented with a few loot options to equip your organism with new abilities. Sometimes, those options will suck, but there’s a tempting little notice at the top left that lets you know you can spend cells to refresh your loot options to maybe get a better selection.

In the first five or so waves, this isn’t worth it. The ten cells it requires might sound paltry if you’ve made it to later waves, but at the beginning, you should be doing your best to save those cells for culture and stat upgrades later on.

Reduce, Reuse, Recycle

Before too long, you’ll probably have an inventory full of organs you don’t need, or maybe even have some equipped that you don’t really want. It’s ok, Bio Prototype throws a lot of these at you in a short amount of time, especially if you’re doing well.

If you need to make some space or maybe you want to score some extra cells for those important upgrades, you can use the recycle option in the organ menu to effectively sell those organs. It’s not exactly the black market, but it does pay off!

It Grows the Economy

When allocating cells in the culture shop, try to spend early cells on upgrades that will grow your economy, meaning things that will allow you to earn more money or organs, quickly. Upgrades like Organ Drop Rate, Organ Quality, and Cell Duplication Chance are all good things to look into early on.

Investing in these will create a snowball effect where runs get progressively more profitable for you, which will in turn allow you to invest in more upgrades. It’s pretty awesome, and I wish I had thought of this when I started playing the game!

Multiply Your Attack Power

The more waves you survive, the enemies you face will be greater in number and abilities. If you aren’t focusing on increasing your power in between waves, you’ll never make it very far. The best way to multiply your attack power quickly is to start your brain off with a tentacle, which will typically fire many projectiles.

After that, equip a cochlea or nerve, followed by another tentacle. Then, you’ll be flinging waves of projectiles at your enemies, and you’ll have a much easier time progressing through waves.

At least for a while. Don’t forget to upgrade and change your loadout as necessary.

Use Fast Organs to Start Your Brain

The organs you equip at the beginning of your brain get a damage boost, and it will also be the first attack that your character throws out every time. For this reason, it doesn’t really make sense to dump your most powerful organ in that spot. Instead, you should put the fastest organ you have in that first spot.

This way, you’ll get a damage boost to a fast attack, which will be incredibly helpful in the early waves and maybe even into the late game. The less amount of time you have in-between attacks, the safer you’ll be overall. Don’t forget the enemies won’t slow down to wait for your attacks to cooldown!

Mike Alexander

Mike has been playing video games since he was able to hold a controller, having been fascinated by Sonic 2 on his mom’s Sega Genesis. That fascination and passion for the art form has grown exponentially nearly 30 years later, and he doesn’t see that fading away anytime soon.
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